![]() ( Yao, et al., 2019 Chen, et al., 2017), neurodegenerative disorders ( Andrew, et al., 2017) and diabetes ( Berchtold, et al., 2011).Īlthough many efforts have been made in this field, In addition, dysregulation of S-palmitoylation is associated with numerous human diseases such as cancer ( Kim, et al., 2019), and immunological response ( Yao, et al., 2019). , and participates in regulating a broad spectrum of biological processes, such as signal transductionĪnd Linder, 2004), neuronal transmission ( Roth, ![]() S-palmitoylation effectively increases the hydrophobicity of protein surfaces to dynamically regulate membrane-protein interactions ![]() ![]() Unlike other tethering lipid modifications, S-palmitoylation reversibly adds one or multiple palmitoyl moieties to internal cysteine residues in proteins through the thioesterification reaction As an important and special class of post-translational modifications (PTMs), lipid modifications mainly comprise S-palmitoylation (C16), N-myristoylation (C14), S-farnesylation (C15), S-geranylgeranylation (C20), cholesterylation and glycosylphosphatidylinositol (GPI)-anchor, depending on the type of lipids covalently attached to modified substrate proteins ![]()
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